Neuroblastoma: Discoveries and Challenges (Pediatric Oncology) (Original PDF from Publisher)

Published in 2024 by Springer as part of the Pediatric Oncology series, Neuroblastoma: Discoveries and Challenges is a pioneering reference text dedicated to the study of neuroblastoma—a leading cause of cancer-related death in young children. This first edition consolidates the latest scientific discoveries and clinical practices in a single volume, offering valuable insights into tumor biology, genetic underpinnings, treatment resistance, and emerging therapies.

This ebook is designed for pediatric oncologists, medical researchers, oncology fellows, geneticists, and clinicians involved in the diagnosis and treatment of childhood cancers. It is also a valuable resource for students in pediatric oncology and translational medicine programs who seek a rigorous yet accessible understanding of neuroblastoma.

Key Features and Highlights

• Interdisciplinary approach combining molecular biology, genetics, immunotherapy, and clinical care
• Detailed discussion on tumor heterogeneity, high-risk disease, and therapeutic resistance
• Focus on MYCN amplification, ALK mutations, and tumor microenvironment
• Insights into novel therapies including CAR T-cell therapy, immunomodulators, and precision oncology
• Richly illustrated with imaging studies, pathway diagrams, and case-based discussions
• Includes contributions from global leaders in pediatric oncology and translational research

Chapters and Topics Covered

• Includes core chapters on neuroblastoma pathophysiology, genetic and epigenetic drivers, tumor staging, standard-of-care treatments, relapse mechanisms, and current/future therapeutic strategies
• Examination of the role of biomarkers in risk stratification
• Discussion of global disparities in treatment outcomes and international collaborative research efforts
• Ethical considerations in pediatric cancer trials and survivorship care

About the Author(s)

The book is authored and edited by leading pediatric oncologists and researchers affiliated with major cancer research centers and children’s hospitals worldwide. Their collective expertise bridges laboratory research and bedside care, ensuring scientifically grounded and clinically applicable content.

Format Details

• Available Formats: PDF
• File Size: Approx. 10.6 MB
• Language: English
• Device Compatibility: Fully compatible with Kindle, Kobo, iPad, smartphones, laptops, and desktop reading platforms. Accessible via Adobe Digital Editions, Apple Books, and other major ebook readers.

FAQs

Q1: Is this book appropriate for medical students or only specialists?
A: While the content is advanced, it is presented in a clear, structured format, making it suitable for medical students with a focus on oncology, as well as residents and early-career clinicians seeking a deeper understanding of pediatric neuroblastoma.

Q2: Does the book cover emerging treatments like CAR T-cell therapy for neuroblastoma?
A: Yes. The book includes detailed coverage of cutting-edge treatments including CAR T-cell therapy, immunotherapy, and other targeted approaches that are reshaping the neuroblastoma treatment landscape.