Drug Metabolism and Pharmacokinetics: Frontiers, Strategies, and Applications (Original PDF from Publisher)

Description

Drug Metabolism and Pharmacokinetics: Frontiers, Strategies, and Applications is a comprehensive academic and professional guide that delves into the essential processes of drug absorption, distribution, metabolism, and excretion (ADME). Authored by leading experts and published by Elsevier, this 1st edition offers forward-thinking insights into optimizing therapeutic efficacy and safety through precise pharmacokinetic modeling and metabolic profiling.

Targeted toward pharmaceutical scientists, clinical pharmacologists, regulatory specialists, and advanced graduate students, this resource bridges theoretical foundations with practical applications critical in drug discovery, development, and regulatory approval.

Key Features and Highlights:

• In-depth coverage of drug metabolism pathways and enzymatic mechanisms
• Critical analysis of pharmacokinetic modeling strategies and in silico tools
• Highlights emerging technologies in drug interaction prediction and bioavailability optimization
• Integrates case studies from real-world clinical trials and preclinical evaluations
• Essential resource for FDA/EMA regulatory alignment in drug evaluation processes
• Authored by seasoned professionals with decades of pharmaceutical R&D experience
• Published by Elsevier – a global leader in scientific and medical publishing

Major Chapters or Topics Covered:

• Includes core chapters on enzymatic drug metabolism and transporter interactions
• Preclinical and clinical pharmacokinetic studies
• PBPK (physiologically based pharmacokinetic) modeling and simulation
• Drug-drug interactions and personalized medicine implications
• Innovative strategies for ADME profiling in early-phase drug development

About the Author(s):
The contributors are internationally recognized experts in pharmacokinetics and drug metabolism, with backgrounds in academia, industry, and regulatory science. Their combined expertise offers readers both depth and practical context in a fast-evolving field.

File Format and Technical Details:

• Format: Original PDF (publisher-formatted)
• File Size: Approximately 20–35 MB
• Language: English
• Device Compatibility: Optimized for reading on desktops, laptops, tablets, and all major PDF-compatible devices and apps (iOS, Android, Windows, macOS)

Frequently Asked Questions (FAQs):

1. Is this book suitable for someone new to pharmacokinetics?
While the content is advanced, foundational concepts are explained clearly, making it accessible to graduate students and early-career professionals in pharmaceutical sciences.

2. Can I use this book for regulatory submission preparation?
Yes. The book includes content directly applicable to FDA and EMA regulatory expectations, making it a valuable reference for professionals involved in submission documentation and compliance.