Heme Oxygenase: Clinical Applications and Functions (Original Publisher)

Heme Oxygenase: Clinical Applications and Functions (1st Edition, 1992) delivers a comprehensive examination of the enzymatic breakdown of heme and the critical role of heme oxygenase (HO) in human health and disease. This pioneering text explores the biochemistry, molecular biology, and therapeutic implications of HO, highlighting its protective role in oxidative stress, inflammation, and cytoprotection.

The book is ideal for biomedical researchers, clinicians in internal medicine and hematology, pharmacologists, and graduate students seeking a deep understanding of the heme degradation pathway and its emerging clinical relevance. It serves as both a scientific foundation and a clinical guide for interpreting the enzyme’s applications in disease states such as cardiovascular disorders, neurodegeneration, and cancer.

Key Features and Highlights:

• Detailed analysis of heme oxygenase isoforms (HO-1 and HO-2) and their biological roles.
• Covers mechanisms of heme degradation and the production of biologically active molecules like biliverdin, bilirubin, and carbon monoxide.
• Explores HO’s protective functions in oxidative stress and its anti-inflammatory effects.
• Includes early clinical research on the enzyme’s role in vascular disease, organ transplantation, and immune modulation.
• Invaluable for understanding therapeutic strategies targeting HO expression and activity.

Major Topics Covered:

• Includes core chapters on heme metabolism, heme oxygenase gene regulation, cellular signaling, antioxidant defense mechanisms, and the enzyme’s role in pathophysiological conditions.
• Discusses experimental models and early clinical studies exploring HO in disease contexts.

About the Author:
Written by leading experts in biochemical pharmacology and enzymology, the contributing authors were among the first to elucidate the multifaceted roles of heme oxygenase in clinical medicine and cellular biology.

Technical Details:

• File Format: PDF
• File Size: Approx. 10 MB
• Language: English
• Publisher: CRC Press
• Year of Publication: 1992
• Device Compatibility: Compatible with Kindle, Apple Books, Kobo, Android, Windows, and other major e-reading platforms

Frequently Asked Questions (FAQs)

Q1: Is this book suitable for clinicians, or is it more research-focused?
A1: The book is designed for both audiences. While it offers extensive scientific and biochemical detail, it also addresses clinical applications, making it highly relevant for physicians and medical researchers alike.

Q2: Does this book cover both HO-1 and HO-2 isoforms?
A2: Yes. The text provides thorough coverage of both HO-1 and HO-2, including their expression patterns, regulatory mechanisms, and respective physiological roles.